Case report reveals unexpected 18F-DOPA uptake in a pediatric posterior mediastinal Ewing sarcoma, highlighting that radiotracer avidity is not entirely specific to neuroendocrine tumors.
¹⁸F-DOPA PET/CT is a well-established imaging modality in pediatric nuclear medicine, with applications in both oncologic and nononcologic conditions. Common indications include brain tumors, neuroendocrine neoplasms, neuroblastoma, and congenital hyperinsulinism. Here, we present an unusual case of ¹⁸F-DOPA uptake in Ewing sarcoma. This case illustrates a potential diagnostic pitfall, emphasizing that ¹⁸F-DOPA avidity is not specific for neuroendocrine or neuroblastic tumors and may occur in non-neuroendocrine malignancies.
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Chaurasiya et al. (2026) studied this question.
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