Randomized double-blind trial shows increased biotin biomarkers in the maternal-fetal dyad, indicating mitigated physiological stress indicators.
= 0.044). In conclusion, a higher-biotin prenatal multivitamin formulation with biotin content exceeding the AI led to increases in biotin biomarkers in the mother-fetus dyad. The higher concentrations of biotin status biomarkers were related to mitigation of stress indicators. Further research is needed to confirm the positive role of a higher biotin intake in improving maternal and fetal health. This trial was registered on ClinicalTrials.gov (NCT05673070).
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Hanson et al. (2026) studied this question.
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