Key result
Na(V)1.5, Ca(V)1.2a, and K(V)1.5 channels specifically localize to isolated caveolar membranes and cluster with caveolin-3, which may influence how adrenergic pathways alter cardiac action potentials.
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May modulate adrenergic effects on cardiac excitability; leaves open translation to arrhythmia management or human electrophysiology.
Shibata et al. (2006) studied this question. Na(V)1.5, Ca(V)1.2a, and K(V)1.5 channels specifically localize to isolated caveolar membranes and cluster with caveolin-3, which may influence how adrenergic pathways alter cardiac action potentials.
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