Structural and Functional Remodeling of the Left Atrium
Key result
Left atrial remodeling is linked to AF, making its prevention a major public health priority.
Why the study?
Left atrial remodeling has an important pathophysiological association with atrial fibrillation, and measures that prevent, attenuate, or halt it may address the AF epidemic.
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
Understanding and targeting the mechanisms of left atrial remodeling may offer therapeutic strategies to prevent or attenuate the progression of atrial fibrillation.
Key Points
- Examine the pathophysiological mechanisms, clinical consequences, and diagnostic markers associated with structural and functional remodeling of the left atrium.
- Synthesized pathophysiological mechanisms involving cellular hypertrophy, interstitial fibrosis, and mechanical stretch in left atrial remodeling.
- Evaluated noninvasive imaging modalities and diagnostic strategies used to quantify atrial chamber size, reservoir strain, and contractile performance.
- Progressive structural alterations, including left atrial enlargement and tissue fibrosis, lead to impaired reservoir, conduit, and booster pump functions.
- Left atrial remodeling strongly predisposes individuals to atrial fibrillation, thromboembolic events, and heart failure progression.
PICO
P
Population
Left atrial remodeling and atrial fibrillation
Understanding and targeting the mechanisms of left atrial remodeling may offer therapeutic strategies to prevent or attenuate the progression of atrial fibrillation.
Cite This Study
Casaclang‐Verzosa et al. (2008) conducted a review in Left atrial remodeling and atrial fibrillation. Left atrial structural and functional remodeling is pathophysiologically associated with atrial fibrillation, and measures to prevent or reverse these processes may have a major public health impact.