Key result
Myocardial ischaemia leads to ATP depletion and subsequent ionic imbalances (Na+, K+, Mg2+, Ca2+), which contribute to the genesis of cardiac arrhythmias.
Design
Review
Authors
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May guide ischemia-specific antiarrhythmic development; leaves open clinical translation of ion-targeted therapies.
Provides a mechanistic overview of how metabolic failure and ionic imbalances during myocardial ischemia contribute to arrhythmogenesis.
Winifred G. Nayler (1981) conducted a review in Cardiac Arrhythmias and Myocardial Ischaemia. Myocardial ischaemia leads to ATP depletion and subsequent ionic imbalances (Na+, K+, Mg2+, Ca2+), which contribute to the genesis of cardiac arrhythmias.
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