Key result
Continuous chronic maternal hyperoxygenation therapy was successfully used to treat fetal hypoplastic left heart in two pregnancies.
Why the study?
Chronic maternal hyperoxygenation can improve left heart growth in fetuses with left-sided cardiac defects, but concerns remain regarding fetal complications involving growth restriction and brain development.
Does continuous chronic maternal hyperoxygenation therapy improve fetal left heart growth in pregnancies with hypoplastic left heart?
Case Report (n=2)
Does continuous chronic maternal hyperoxygenation therapy improve fetal left heart growth in pregnancies with hypoplastic left heart?
Continuous chronic maternal hyperoxygenation therapy may be a viable prenatal treatment option to improve left heart growth in fetuses with hypoplastic left heart.
Answers are grounded in this paper and cite their sources.
May warrant evaluation in select fetal hypoplastic left heart cases; leaves open efficacy and safety pending controlled trials.
Maternal hyperoxygenation (MH) has been studied as a diagnostic tool to evaluate pulmonary vasculature and as a treatment option to improve the growth of fetal left heart in fetuses with left-sided cardiac defects. Chronic maternal hyperoxygenation (CMH) therapy leads to an improvement in fetal pulmonary blood flow resulting in an enhanced venous return to the left heart with increased gestational age. With this manipulation it is anticipated to augment blood flow directed remodeling of the left heart structures and to improve left heart growth spanning from the mitral valve to the aortic isthmus. However, there are concerns about CMH therapy with regard to fetal complications with growth restriction and fetal brain development. Now, with two successful cases we try to discuss this fetal treatment option and related concerns.
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Gedikbaşı et al. (2023) conducted a case report in Hypoplastic Left Heart (n=2). Continuous Chronic Maternal Hyperoxygenation (CMH) Therapy was evaluated. Continuous chronic maternal hyperoxygenation therapy was successfully used to treat fetal hypoplastic left heart in two pregnancies.
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