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December 22, 2025Shoulder & ElbowOpen Access

Outcomes and complications of allograft-prosthetic composite versus megaprosthesis for shoulder arthroplasty with non-oncologic indications: A systematic review

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Authors

LYL Lanvy YoungVirginia Commonwealth UniversityCCC. CecilVirginia Commonwealth UniversitySCSarah ColeVirginia Commonwealth University

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Overview

Systematic review reveals higher complication and revision rates for megaprosthesis in non-oncologic shoulder arthroplasty, indicating allograft composites may offer a safer alternative.

Key Points

  • To compare the clinical outcomes, range of motion, and complication profiles of allograft-prosthetic composite reconstruction versus megaprosthesis in non-oncologic shoulder arthroplasty.
  • Conducted a systematic search across PubMed, Embase, and Cochrane for studies published through April 2025 evaluating non-oncologic shoulder reconstruction.
  • Identified five eligible studies comprising 157 patients (130 allograft-prosthetic composite, 27 megaprosthesis) with a mean age of 66 years, including 155 patients with prior surgical interventions.
  • Extracted and synthesized data regarding range of motion, postoperative functional metrics, adverse complications, and revision surgery rates.
  • Both procedures significantly improved forward flexion (p < 0.05), while allograft composites demonstrated significant gains in abduction (p < 0.05) and megaprostheses showed significant improvements in internal and external rotation (p < 0.05).
  • Across all included studies, 48 complications and 33 revisions were reported, with both events occurring at higher rates following megaprosthesis than allograft-prosthetic composite reconstruction.

Cite This Study

Young et al. (2025) studied this question.

synapsesocial.com/papers/6a9d3c339675ea025129f6d3https://doi.org/10.1177/17585732251403536
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