Why the study?
Does co-administration of SNAP or CapSNO with cysteine reduce glucose tolerance in normoglycemic rats?
Does co-administration of SNAP or CapSNO with cysteine reduce glucose tolerance in normoglycemic rats?
Absolute Event Rate: 6.47% vs 5.46%
p-value: p=<0.05
Co-administration of cysteine with NO donors SNAP or CapSNO exacerbates decreased glucose tolerance and increases postprandial hyperglycemia in normoglycemic rats.
Cysteine may worsen glucose tolerance with these NO donors in rats; hypothesis-generating for thiol-NO interactions in glycemia.
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Campbell et al. (2008) studied Normoglycemia. S-Nitroso-Captopril (CapSNO) co-administered with cysteine vs. CapSNO alone (12.5 mg/kg BW) was evaluated on Postprandial blood glucose concentration at 2.5 hours (p=<0.05).
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