Key result
Captopril increases total glucose uptake ~41% and reduces baseline plasma norepinephrine and epinephrine levels.
Authors
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May improve insulin sensitivity in type 2 diabetes; hypothesis-generating and requires validation in larger trials.
RCT (n=14)
Double-blind
Randomized
Absolute Event Rate: 26.8% vs 19%
p-value: p=<0.05
Mattia et al. (1996) conducted an RCT in Non-insulin-dependent diabetes mellitus (NIDDM) (n=14). Captopril vs. Placebo was evaluated on Total glucose uptake (p=<0.05). Captopril treatment significantly increased total glucose uptake from 19.0 to 26.8 mmol/kg/min (P<0.05) and reduced baseline plasma norepinephrine and epinephrine levels.
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