December 1, 1993Australian and New Zealand Journal of Medicine

A comparison between enalapril and captopril on insulin sensitivity in normotensive healthy volunteers

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Why the study?

Do ACE inhibitors (captopril and enalapril) affect insulin sensitivity in normotensive, non-obese, insulin sensitive subjects?

Population

Normotensive, non-obese, insulin sensitive healthy volunteers

Comparison

Captopril and enalapril for 28 days vs Cross-over design comparing captopril and…

Design

Other, single blind

Follow-up

28 days per treatment period

Authors

MPM. C. PrattAbbott (United States)NLNick Lewis‐BarnedNorthumbria Healthcare NHS Foundation Trust RWRobert WalkerDunedin Public Hospital

Discussion

Member takes

Implication

ACE inhibitors may reduce insulin sensitivity in healthy subjects; leaves open differential effects by metabolic or hypertensive status.

Structured PICO

Do ACE inhibitors (captopril and enalapril) affect insulin sensitivity in normotensive, non-obese, insulin sensitive subjects?

Population

Normotensive, non-obese, insulin sensitive healthy volunteers

Intervention

Captopril (6.25 mg twice daily) and enalapril (5 mg once daily) for 28 days

Comparator

Cross-over design comparing captopril and enalapril, with a 28-day washout period between drugs

Outcome

Insulin mediated glucose uptake (measured by euglycaemic hyperinsulinaemic clamp) and fasting insulin levels at the start and completion of each period of drug therapysurrogate

In contrast to findings in obese and hypertensive patients, ACE inhibitors appear to reduce insulin sensitivity and increase fasting insulin levels in healthy, normotensive subjects.

Cite This Study

Pratt et al. (1993) studied this question.

synapsesocial.com/papers/6a71f12a35aa2c282ce302fb https://doi.org/10.1111/j.1445-5994.1993.tb04721.x

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December 1, 1993Australian and New Zealand Journal of Medicine

A comparison between enalapril and captopril on insulin sensitivity in normotensive healthy volunteers

View Full Paper

Ask AI

Bookmark

Why the study?

Do ACE inhibitors (captopril and enalapril) affect insulin sensitivity in normotensive, non-obese, insulin sensitive subjects?

Population

Normotensive, non-obese, insulin sensitive healthy volunteers

Comparison

Captopril and enalapril for 28 days vs Cross-over design comparing captopril and…

Design

Other, single blind

Follow-up

28 days per treatment period

Authors

MPM. C. PrattAbbott (United States)NLNick Lewis‐BarnedNorthumbria Healthcare NHS Foundation Trust RWRobert WalkerDunedin Public Hospital

Discussion

Member takes

Implication

ACE inhibitors may reduce insulin sensitivity in healthy subjects; leaves open differential effects by metabolic or hypertensive status.

Structured PICO

Do ACE inhibitors (captopril and enalapril) affect insulin sensitivity in normotensive, non-obese, insulin sensitive subjects?

Population

Normotensive, non-obese, insulin sensitive healthy volunteers

Intervention

Captopril (6.25 mg twice daily) and enalapril (5 mg once daily) for 28 days

Comparator

Cross-over design comparing captopril and enalapril, with a 28-day washout period between drugs

Outcome

Insulin mediated glucose uptake (measured by euglycaemic hyperinsulinaemic clamp) and fasting insulin levels at the start and completion of each period of drug therapysurrogate

In contrast to findings in obese and hypertensive patients, ACE inhibitors appear to reduce insulin sensitivity and increase fasting insulin levels in healthy, normotensive subjects.

Cite This Study

Pratt et al. (1993) studied this question.

synapsesocial.com/papers/6a71f12a35aa2c282ce302fb https://doi.org/10.1111/j.1445-5994.1993.tb04721.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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