Key result
In pediatric patients with left-to-right shunt congenital heart disease, serum levels of Rho kinase and ET-1 were positively correlated with pulmonary artery systolic pressure (r=0.707 and r=0.888), while NO was negatively correlated (r=-0.696).
Why the study?
The study aimed to investigate the serum expression levels of Rho kinase, ET-1, and NO in pediatric patients with left-to-right shunt CHD and their correlation with PASP.
Do serum levels of Rho kinase, ET-1, and NO correlate with pulmonary artery systolic pressure in pediatric patients with left-to-right shunt congenital heart disease?
Observational (n=120)
No
Do serum levels of Rho kinase, ET-1, and NO correlate with pulmonary artery systolic pressure in pediatric patients with left-to-right shunt congenital heart disease?
Effect estimate: r = 0.707 (Rho kinase), r = 0.888 (ET-1), r = -0.696 (NO)
p-value: p=<0.01
Serum levels of Rho kinase and ET-1 are positively correlated, and NO is negatively correlated, with pulmonary artery systolic pressure in pediatric patients with left-to-right shunt congenital heart disease, suggesting their involvement in the development of pulmonary hypertension.
Serum Rho kinase, ET-1, and NO levels associate with PASP in pediatric shunt CHD; hypothesis-generating and should not yet change practice.
Background: The study aimed to investigate the serum expression levels of Rho kinase, endothelin-1 (ET-1), and nitric oxide (NO) in pediatric patients with left-to-right shunt congenital heart disease (CHD) and their correlation with pulmonary artery systolic pressure (PASP). Methods: 90 pediatric patients diagnosed with left-to-right shunt CHD and hospitalized were selected as the study objects.They were divided into three groups according to their PASP: the non-pulmonary artery hypertension (non-PAH) group (PASP <30 mmhg), the mild PAH group (PASP 30–49 mmhg), and the moderate to severe PAH group (PASP ≥50 mmhg). Healthy children were selected as the control group. Enzyme-linked immunosorbent assay, radioimmunoassay, and nitrate reductase assay were used to determine the patients’ serum levels of Rho kinase, ET-1, and NO, respectively. The correlation between PASP and the above indexes was analyzed. Results: In pediatric patients with left-to-right shut CHD, the serum expression levels of Rho kinase and ET-1 were higher than in the control group members, while the serum expression level of NO was lower. In pediatric patients with CHD accompanied by pulmonary hypertension (PH), the expression levels of Rho kinase and ET-1 were even higher, and the level of NO even lower, than in patients and control group members without PH. The serum levels of Rho kinase and ET-1 were positively correlated with PASP , while the serum level of NO was negatively correlated with PASP. Conclusion: Rho kinase, ET-1, and NO may be involved in the development of PH in pediatric patients with left-to-right shunt CHD.
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Sun et al. (2021) conducted an observational in Left-to-right shunt congenital heart disease with pulmonary hypertension (n=120). Serum Rho kinase, ET-1, and NO levels vs. Healthy children and CHD patients without pulmonary hypertension was evaluated on Correlation between serum levels of Rho kinase, ET-1, NO and pulmonary artery systolic pressure (PASP) (r = 0.707 (Rho kinase), r = 0.888 (ET-1), r = -0.696 (NO), p=<0.01). In pediatric patients with left-to-right shunt congenital heart disease, serum levels of Rho kinase and ET-1 were positively correlated with pulmonary artery systolic pressure (r=0.707 and r=0.888), while NO was negatively correlated (r=-0.696).
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