Key result
In pediatric patients with left-to-right shunt congenital heart disease, serum levels of Rho kinase and ET-1 were significantly elevated and positively correlated with pulmonary artery systolic pressure.
Why the study?
The study aimed to investigate serum expression levels of Rho kinase, ET-1, and NO in pediatric patients with left-to-right shunt CHD and their correlation with PASP.
Do serum levels of Rho kinase, ET-1, and NO correlate with pulmonary artery systolic pressure in pediatric patients with left-to-right shunt congenital heart disease?
Cross-Sectional (n=120)
No
Do serum levels of Rho kinase, ET-1, and NO correlate with pulmonary artery systolic pressure in pediatric patients with left-to-right shunt congenital heart disease?
Absolute Event Rate: 42.98% vs 18.9%
p-value: p=<0.001
Serum levels of Rho kinase and ET-1 are elevated and positively correlated with pulmonary artery systolic pressure in pediatric patients with left-to-right shunt congenital heart disease, while NO levels are decreased and negatively correlated.
May link Rho kinase/ET-1/NO to PASP in pediatric shunt CHD; hypothesis-generating and requires prospective validation before clinical use.
Background The study aimed to investigate the serum expression levels of Rho kinase, endothelin-1 (ET-1), and nitric oxide (NO) in pediatric patients with left-to-right shunt congenital heart disease (CHD) and their correlation with pulmonary artery systolic pressure (PASP). Methods 90 pediatric patients diagnosed with left-to-right shunt CHD and hospitalized were selected as the study objects.They were divided into three groups according to their PASP: the non-pulmonary artery hypertension (non-PAH) group (PASP < 30 mmhg), the mild PAH group (PASP 30–49 mmhg), and the moderate to severe PAH group (PASP ≥ 50 mmhg). Healthy children were selected as the control group. Enzyme-linked immunosorbent assay, radioimmunoassay, and nitrate reductase assay were used to determine the patients’ serum levels of Rho kinase, ET-1, and NO, respectively. The correlation between PASP and the above indexes was analyzed. Results In pediatric patients with left-to-right shut CHD, the serum expression levels of Rho kinase and ET-1 were higher than in the control group members, while the serum expression level of NO was lower. In pediatric patients with CHD accompanied by pulmonary hypertension (PH), the expression levels of Rho kinase and ET-1 were even higher, and the level of NO even lower, than in patients and control group members without PH. The serum levels of Rho kinase and ET-1 were positively correlated with PASP, while the serum level of NO was negatively correlated with PASP. Conclusion Rho kinase, ET-1, and NO may be involved in the development of PH in pediatric patients with left-to-right shunt CHD.
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Sun et al. (2020) conducted a cross-sectional in Left-to-right shunt congenital heart disease with pulmonary hypertension (n=120). Left-to-right shunt congenital heart disease with pulmonary hypertension vs. Healthy children and CHD patients without pulmonary hypertension was evaluated on Serum Rho kinase level (pmol/L) (p=<0.001). In pediatric patients with left-to-right shunt congenital heart disease, serum levels of Rho kinase and ET-1 were significantly elevated and positively correlated with pulmonary artery systolic pressure.
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