Key result
A recombinant human enterovirus-B variant, identified as a genomic chimera of coxsackievirus B3, EV 86, and EV97, caused fatal neonatal myocarditis.
Identifies a novel recombinant human enterovirus-B variant as a cause of fatal neonatal myocarditis.
May prompt testing for recombinant enteroviruses in neonatal myocarditis; leaves open prevalence and surveillance needs.
We report a case of fatal myocarditis in a newborn infant who was infected with a human enterovirus detected by throat culture and RT-PCR for viral RNA in plasma. Whole genome sequence analysis revealed the virus to be a genomic chimera that likely arose from recombination between coxsackievirus B3 and two recently identified enteroviruses, EV 86 and EV97.
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Krogstad et al. (2008) studied this question. A recombinant human enterovirus-B variant, identified as a genomic chimera of coxsackievirus B3, EV 86, and EV97, caused fatal neonatal myocarditis.
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