Key result
The combination of telmisartan plus amlodipine was equally effective as telmisartan plus chlorthalidone in significantly reducing systolic and diastolic blood pressure from baseline over 8 weeks.
Why the study?
The study was conducted to evaluate and compare the safety and efficacy of telmisartan plus amlodipine versus telmisartan plus chlorthalidone on blood pressure in hypertensive patients.
Does telmisartan plus amlodipine reduce blood pressure compared to telmisartan plus chlorthalidone in hypertensive patients resistant to monotherapy?
RCT (n=120)
Open-label
Randomly allocated
No
Does telmisartan plus amlodipine reduce blood pressure compared to telmisartan plus chlorthalidone in hypertensive patients resistant to monotherapy?
In patients with hypertension resistant to monotherapy, the combination of telmisartan plus amlodipine is equally effective and safe as telmisartan plus chlorthalidone in reducing blood pressure over 8 weeks.
Answers are grounded in this paper and cite their sources.
Telmisartan-amlodipine showed comparable BP effects to plus chlorthalidone in this open-label study; leaves open confirmation in larger blinded trials.
Objective: The main objective of this study is to evaluate and compare the effects of both treatments on systolic and diastolic blood pressure in 4th, and 8th weeks with baseline Methods: A prospective, comparative, Open-label, and parallel-group clinical study was conducted in out patient's department of general medicine at Osmania general hospital. 120 patients were randomly allocated into 2 groups. Group 1 with 60 patients received Tab: Telmisartan 40 mg+Amlodipine 5 mg once daily, and Group 2 with 60 patients received Tab: Telmisartan 40 mg+ Chlorthalidone 6.25 mg once daily for a period of 8 w. Follow-up was done in the 4th week and 8th week to evaluate the safety and efficacy in hypertensive patients. Results: The differences in the SBP, DBP, and HR in group A (P value<0.001) and group B (P value<0.001) at the 4th week and 8th week follow-up periods with baseline value (0 w) were statistically significant as P value<0.05. Conclusion: The combination of telmisartan plus amlodipine is equally effective as the combination of telmisartan plus chlorthalidone in decreasing SBP, DBP, HR, and MAP. No major adverse drug reactions were noted during the study period.
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Kumar et al. (2022) conducted an RCT in Hypertension (n=120). Telmisartan plus Amlodipine vs. Telmisartan 40 mg + Chlorthalidone 6.25 mg once daily was evaluated on Systolic blood pressure at 8 weeks (p=<0.001). The combination of telmisartan plus amlodipine was equally effective as telmisartan plus chlorthalidone in significantly reducing systolic and diastolic blood pressure from baseline over 8 weeks.
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