Why the study?
The study was conducted to assess the efficacy and safety of low-dose triple combinations of amlodipine, telmisartan, and chlorthalidone in patients with essential hypertension.
Does a low-dose triple combination of amlodipine, telmisartan, and chlorthalidone reduce blood pressure in patients with essential hypertension?
Population
176 patients with essential hypertension
Comparison
Low-dose triple combinations vs placebo, amlodipine 5 mg, amlodipine 10 mg, or telmisartan 80 mg
Design
Randomized, double-blind, parallel, phase II trial
Follow-up
8 weeks
Authors
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Supports low-dose triple therapy initiation in essential hypertension; extends monotherapy evidence to fixed-dose regimens.
Does a low-dose triple combination of amlodipine, telmisartan, and chlorthalidone reduce blood pressure in patients with essential hypertension?
Low-dose triple combination therapy with amlodipine, telmisartan, and chlorthalidone is effective and safe for blood pressure reduction in essential hypertension.
Sung et al. (2022) studied this question.