Why the study?
Low-dose combination therapy is a promising approach for managing hypertension, but the safety and efficacy of a single-pill triple combination of amlodipine, telmisartan, and chlorthalidone required systematic evaluation.
Does a single-pill combination of amlodipine, telmisartan, and chlorthalidone improve blood pressure control in patients with essential hypertension?
Comparison
Single-pill amlodipine, telmisartan, and chlorthalidone vs usual care, amlodipine 10 mg, or telmisartan/amlodipine dual therapy
Design
Systematic review of randomized controlled trials
Key result
A single-pill combination of amlodipine, telmisartan, and chlorthalidone significantly reduced systolic and diastolic blood pressure and improved control rates compared to control treatments.
Authors
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Supports this triple single-pill combination for essential hypertension; confirms efficacy of low-dose triple therapy over dual regimens.
Systematic Review (n=1,124)
Does a single-pill combination of amlodipine, telmisartan, and chlorthalidone improve blood pressure control in patients with essential hypertension?
A low-dose, single-pill triple combination of amlodipine, telmisartan, and chlorthalidone safely and effectively improves blood pressure control in patients with essential hypertension compared to usual care or dual therapy.
Elbardisy et al. (2024) conducted a systematic review in Essential hypertension (n=1,124). Single-pill combination of amlodipine, telmisartan, and chlorthalidone vs. Usual care, amlodipine 10 mg, or dual therapy of telmisartan and amlodipine was evaluated on Mean change in sitting systolic blood pressure. A single-pill combination of amlodipine, telmisartan, and chlorthalidone significantly reduced systolic and diastolic blood pressure and improved control rates compared to control treatments.