Key result
Telmisartan produces more effective control of blood pressure over 24 hours compared with other antihypertensive agents, though it currently lacks evidence for reducing vascular events.
Why the study?
Does telmisartan improve blood pressure control over 24 h compared with other antihypertensive agents in patients with hypertension?
Does telmisartan improve blood pressure control over 24 h compared with other antihypertensive agents in patients with hypertension?
Telmisartan provides effective 24-hour blood pressure control and has pleiotropic metabolic effects, though hard clinical outcome data were pending at the time of publication.
BACKGROUND: Telmisartan is an orally active angiotensin II receptor antagonist prescribed once daily. OBJECTIVE: To evaluate the efficacy of telmisartan on blood pressure control, and on other end points, when given as monotherapy or in combination. METHODS: Review of published literature. RESULTS: Telmisartan produces more effective control of blood pressure over 24 h, especially in the last 6 h of the dosing interval, compared with other antihypertensive agents. It also possesses pleiotrophic effects on lipid and glucose metabolism, but lacks evidence of efficacy in reducing vascular events. CONCLUSIONS: Clinical outcome trials expected to report in 2008 will provide hard end points that may demonstrate advantages of telmisartan as monotherapy, or in combination with angiotensin-converting enzyme inhibitors, for managing hypertension.
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Rosario et al. (2008) conducted a review in hypertension. Telmisartan vs. other antihypertensive agents was evaluated on blood pressure control. Telmisartan produces more effective control of blood pressure over 24 hours compared with other antihypertensive agents, though it currently lacks evidence for reducing vascular events.
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