Key result
Treatment with reserpine and guanethidine induced left ventricular impairment in 100% of hypertensive digitalis responders, compared to 0% of non-responders.
Why the study?
Does antiadrenergic therapy induce cardiac decompensation in hypertensive patients with limited cardiac reserve?
RCT (n=30)
randomly selected
Does antiadrenergic therapy induce cardiac decompensation in hypertensive patients with limited cardiac reserve?
Absolute Event Rate: 100% vs 0%
Antiadrenergic therapy can precipitate overt heart failure in hypertensive patients with latent cardiac insufficiency, which can be predicted by their haemodynamic response to digitalis and mitigated by concurrent diuretic use.
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Antiadrenergic agents may precipitate LV impairment in digitalis-responsive hypertensives; leaves open validation in contemporary cohorts.
Guazzi et al. (1973) conducted an RCT in Essential arterial hypertension (n=30). Reserpine and guanethidine vs. Digitalis non-responders (Group I) was evaluated on Clinical and haemodynamic signs of left ventricular impairment. Treatment with reserpine and guanethidine induced left ventricular impairment in 100% of hypertensive digitalis responders, compared to 0% of non-responders.
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