June 17, 2018European Journal of Gastroenterology & Hepatology
Association of fatty liver index with the risk of incident cardiovascular disease and acute myocardial infarction
Key result
A high fatty liver index (≥60) was associated with an increased risk of incident cardiovascular disease compared to a low index (≤30) after multivariable adjustment (HR 1.41; 95% CI 1.10-1.79).
Why the study?
Does a high fatty liver index predict incident cardiovascular disease and acute myocardial infarction in middle-aged men?
Population
1205 middle-aged men free of CVD at baseline from the Kuopio Ischaemic Heart Disease Risk Factor Study cohort
Comparison
High fatty liver index (FLI ≥ 60) vs Low fatty liver index (FLI ≤ 30)
Design
Cohort
Follow-up
median 17 years
Authors
Discussion
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Member takes
Implication
High fatty liver index may flag elevated CVD risk in middle-aged men; leaves open incremental value for AMI beyond metabolic factors.
Study Design
Type
Cohort (n=1,205)
Structured PICO
Does a high fatty liver index predict incident cardiovascular disease and acute myocardial infarction in middle-aged men?
P
Population
1,205 middle-aged men free of cardiovascular disease at baseline, followed for a median of 17 years.
E
Exposure
High fatty liver index (FLI ≥ 60)
C
Comparator
Low fatty liver index (FLI ≤ 30)
O
Outcome
Incident cardiovascular disease (CVD) and incident acute myocardial infarction (AMI)hard clinical
Main Result
Hazard Ratio: 1.41 (95% CI 1.1–1.79)
A high fatty liver index is an independent predictor of incident cardiovascular disease, though its association with acute myocardial infarction is attenuated by metabolic factors.
Cite This Study
Olubamwo et al. (2018) conducted a cohort in Cardiovascular disease risk (n=1,205). High fatty liver index (FLI ≥60) vs. Low fatty liver index (FLI ≤30) was evaluated on Incident cardiovascular disease (HR 1.41, 95% CI 1.10-1.79). A high fatty liver index (≥60) was associated with an increased risk of incident cardiovascular disease compared to a low index (≤30) after multivariable adjustment (HR 1.41; 95% CI 1.10-1.79).