Key result
Elevated Fatty Liver Index linked to ~39% greater risk of incident CHD.
Why the study?
Debate persists on whether MASLD actively contributes to coronary heart disease or acts as a passive indicator, prompting evaluation of the relationship between FLI and incident coronary heart disease.
Does an elevated Fatty Liver Index (FLI) increase the risk of incident coronary heart disease in adults?
Population
8,647 Chinese adults aged 40 and above without pre-existing CHD or acute MI
Comparison
Participants grouped into three FLI categories (FLI≥60 and 30≤FLI<60 vs FLI<30)
Design
Cohort study
Follow-up
10-year
Authors
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Elevated FLI may flag higher CHD risk in Chinese adults; leaves open incremental value beyond traditional factors.
Cohort (n=8,647)
No
Does an elevated Fatty Liver Index (FLI) increase the risk of incident coronary heart disease in adults?
Hazard Ratio: 1.386 (95% CI 1.014–1.896)
p-value: p=0.041
An elevated Fatty Liver Index (FLI ≥60) is independently associated with a significantly increased risk of incident coronary heart disease over a 10-year period in Chinese adults.
Miao et al. (2024) conducted a cohort in Coronary heart disease (n=8,647). Elevated Fatty Liver Index (FLI ≥60) vs. FLI < 30 was evaluated on Incident coronary heart disease (HR 1.386, 95% CI 1.014-1.896, p=0.041). Participants with a Fatty Liver Index ≥60 had a significantly higher risk of developing incident coronary heart disease compared to those with an index <30 (HR 1.386).
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