Key result
Lysophosphatidic acid signaling plays significant roles in vascular development, function, and disease, including vasculogenesis, angiogenesis, and vascular maturation.
This review highlights the significant roles of lysophosphatidic acid signaling in vascular development, function, and disease.
LPA signaling broadens vascular research targets; leaves open therapeutic modulation pending interventional human studies.
Lysophosphatidic acid (LPA) is a small signaling lipid that is capable of stimulating a plethora of different cellular responses through the activation of its family of cognate G protein-coupled receptors. LPA mediates a wide range of biological effects in many tissue types that have been recently reviewed; however, its effects on vasculature development and function have received comparatively less examination. In this review, literature on the actions of LPA in three main aspects of vascular development (vasculogenesis, angiogenesis, and vascular maturation) is discussed. In addition, evidence for the roles of LPA signaling in the formation of secondary vascular structures, such as the blood brain barrier, is considered, consistent with significant roles for LPA signaling in vascular development, function, and disease.
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Teo et al. (2009) conducted a review in Vascular development and disease. Lysophosphatidic acid (LPA) was evaluated. Lysophosphatidic acid signaling plays significant roles in vascular development, function, and disease, including vasculogenesis, angiogenesis, and vascular maturation.
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