Key result
The DD genotype of the ACE rs4340 polymorphism was significantly associated with an increased risk of metabolic syndrome in women (OR 4.62; 95% CI 1.41-15.04; p<0.01).
Why the study?
Are polymorphisms in the renin-angiotensin system associated with metabolic syndrome in Chilean subjects?
Cohort (n=152)
Are polymorphisms in the renin-angiotensin system associated with metabolic syndrome in Chilean subjects?
Odds Ratio: 4.62 (95% CI 1.41–15.04)
p-value: p=< 0.01
Polymorphisms in the renin-angiotensin system, specifically the ACE DD genotype in women, are associated with an increased risk of metabolic syndrome in Chilean subjects.
Hypothesis-generating in Chilean women; leaves open whether ACE genotyping informs metabolic syndrome risk assessment.
OBJECTIVE: Metabolic syndrome (MetS) is associated with hypertension, obesity and dyslipidemia. Thus, genetic variants related with these conditions may modulate its development. We evaluated the effect of polymorphisms in the renin-angiotensin system (RAS) on metabolic syndrome risk in a cohort of Chilean subjects. SUBJECTS AND METHODS: A total of 152 subjects, 83 with MetS (51.2 ± 9.6 years) and 69 without MetS (49.5 ± 9.3 years) of both genders were included, according to the ATP III update criteria. The rs4340 Insertion/Deletion (I/D), rs699 (T>C) and rs5186 (A>C) of the ACE, AGT and AGTR1 genes, respectively, were genotyped. RESULTS: After adjusting for age and gender, we observed the DD genotype of rs4340 associated with MetS (p = 0.02). Specifically, the DD genotype was associated with MetS risk in women (OR = 4.62, 95%CI, 1.41 - 15.04; p < 0.01). In males, the AA genotype for rs5186 variant was associated with an increased risk for developing MetS when compared with women carrying the same genotype (OR = 3.2; 95%CI, 1.03 - 9.89; p = 0.04). In subjects without MetS, DD genotype was associated with increased waist circumference (p = 0.023) while subjects with MetS carrying the rs5186 TT genotype showed higher levels of HDL-cholesterol (p = 0.031). CONCLUSION: The present study contributes data highlighting the role for RAS polymorphisms in predisposing to metabolic syndrome in Chilean subjects.
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Herrera et al. (2016) conducted a cohort in Metabolic syndrome (n=152). ACE rs4340 DD genotype vs. Non-DD genotypes was evaluated on Metabolic syndrome risk in women (OR 4.62, 95% CI 1.41 - 15.04, p=< 0.01). The DD genotype of the ACE rs4340 polymorphism was significantly associated with an increased risk of metabolic syndrome in women (OR 4.62; 95% CI 1.41-15.04; p<0.01).
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