Key result
Vitamin E supplementation (300 mg/day) had no clinically relevant effect on ambulatory blood pressure in treated hypertensive patients (diastolic BP MD -1.6 mm Hg; 95% CI -2.8 to -0.4; P=0.06).
Why the study?
Does vitamin E supplementation reduce clinic and ambulatory blood pressure in treated hypertensive patients?
RCT (n=142)
Open-label
randomized
Does vitamin E supplementation reduce clinic and ambulatory blood pressure in treated hypertensive patients?
Mean Difference: -1.6 (95% CI -2.8–-0.4)
p-value: p=.06
Vitamin E supplementation does not provide clinically relevant blood pressure reduction in patients already on antihypertensive treatment.
Vitamin E adds no meaningful BP benefit in treated hypertension; confirms lack of efficacy for this antioxidant approach.
A randomized controlled open trial studied the effect of vitamin E supplementation (300 mg/day) on clinic and 24-h ambulatory blood pressure (BP) in 142 treated hypertensive patients. After 12 weeks, clinic BP decreased whether or not patients were randomized to vitamin E. Ambulatory BP showed no change in systolic BP and a small decrease in diastolic BP (-1.6 mm Hg, 95% confidence intervals from -2.8 to -0.4 mm Hg), approaching statistical significance in comparison to the control group (P = .06). Vitamin E supplementation thus seems to have no clinically relevant effect on BP in hypertensive patients already under controlled treatment.
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Palumbo et al. (2000) conducted an RCT in treated hypertension (n=142). Vitamin E vs. control group was evaluated on clinic and 24-h ambulatory blood pressure (MD -1.6 mm Hg, 95% CI -2.8 to -0.4, p=.06). Vitamin E supplementation (300 mg/day) had no clinically relevant effect on ambulatory blood pressure in treated hypertensive patients (diastolic BP MD -1.6 mm Hg; 95% CI -2.8 to -0.4; P=0.06).
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