Key result
Prenylamine 180 mg daily significantly prolonged the QT interval in patients with angina pectoris after one week of treatment, which returned to normal within 2 weeks of withdrawal.
Why the study?
Does prenylamine prolong the QT interval in patients with angina pectoris?
Observational (n=29)
Does prenylamine prolong the QT interval in patients with angina pectoris?
Prenylamine 180 mg daily significantly prolongs the QT interval in patients with angina pectoris, an effect that is reversible upon discontinuation.
May warrant QT monitoring with prenylamine in angina; leaves open arrhythmic outcome data in larger cohorts.
Resting ECGs were recorded in 29 patients with angina pectoris before, during and after treatment with prenylamine 180 mg daily. The QT interval became significantly prolonged after one week of treatment. The prolongation persisted as long as therapy was continued, which was up to 6 months. After withdrawal of treatment the QT interval returned to normal within 2 weeks. In this study no serious problems were encountered by those patients in whom the QT interval was prolonged.
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Oakley et al. (1980) conducted an observational in angina pectoris (n=29). Prenylamine vs. Baseline (before treatment) was evaluated on QT interval. Prenylamine 180 mg daily significantly prolonged the QT interval in patients with angina pectoris after one week of treatment, which returned to normal within 2 weeks of withdrawal.
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