Catalytic Asymmetric Aminoallylation of Aldehydes: A Catalytic Enantioselective Aza‐Cope Rearrangement

A condensation–rearrangement sequence forms the basis of a high-yielding route to chiral homoallylic amines from readily accessible aldehydes (see scheme). This transformation is both the first enantioselective Brønsted acid catalyzed sigmatropic rearrangement and the first example of a catalytic asymmetric aza-Cope rearrangement.