Key result
Selective endothelin A receptor antagonists appear effective in reducing blood pressure and improving proteinuria, but their use is currently limited by significant sodium retention.
Why the study?
Do selective endothelin A receptor antagonists reduce blood pressure and improve proteinuria in patients with resistant hypertension and chronic kidney disease?
Population
Patients with resistant hypertension and chronic kidney disease
Design
Review
Authors
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Endothelin A antagonists should not yet change practice in resistant hypertension or CKD; leaves open whether sodium retention can be mitigated to unlock efficacy.
Do selective endothelin A receptor antagonists reduce blood pressure and improve proteinuria in patients with resistant hypertension and chronic kidney disease?
Selective endothelin A receptor antagonists may be effective for resistant hypertension and proteinuric kidney disease, but their clinical utility is currently limited by significant sodium retention.
Moore et al. (2010) conducted a review in Resistant hypertension and chronic kidney disease. Selective endothelin A receptor antagonists was evaluated. Selective endothelin A receptor antagonists appear effective in reducing blood pressure and improving proteinuria, but their use is currently limited by significant sodium retention.
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