Sindbis virus ts103 has a mutation in glycoprotein E2 that leads to defective assembly of virions
Key result
A mutation in glycoprotein E2 (Ala-344 to Val) of Sindbis virus mutant ts103 leads to defective assembly of virions due to weakened interactions during budding.
Population
Sindbis virus mutant ts103 and parental strain
Comparison
Mutation in glycoprotein E2 (Ala-344 to Val) vs Parental strain of the virus
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for E2-targeted antivirals; leaves open translation beyond this Sindbis model.
Structured PICO
P
Population
Sindbis virus mutant ts103 and parental strain
E
Exposure
Mutation in glycoprotein E2 (Ala-344 to Val)
C
Comparator
Parental strain of the virus
O
Outcome
Virus particle assembly and yield
The study identifies specific glycoprotein mutations responsible for defective virion assembly in Sindbis virus mutant ts103.
Cite This Study
Hahn et al. (1989) studied Sindbis virus. Sindbis virus mutant ts103 vs. Parental strain was evaluated on Virus assembly and budding. A mutation in glycoprotein E2 (Ala-344 to Val) of Sindbis virus mutant ts103 leads to defective assembly of virions due to weakened interactions during budding.