Key result
The presence and viral load of MSRV in blood and CSF were significantly associated with multiple sclerosis compared to neurological (p<0.05) and healthy controls (p<0.001) across all ethnic groups.
Case-Control (n=302)
Yes
The presence and viral load of HERV-W/MSRV are significantly higher in MS patients compared to neurological and healthy controls across different European populations, suggesting it is an important marker of the ongoing process in MS.
We designed a large multicentric study to analyse the presence of MSRV particles in blood and CSF of a large cohort of patients and controls from different European areas. 149 MS patients and 153 neurological and healthy controls were selected from Sardinia, Spain, Northern-Italy and Sweden. To avoid biological and inter-assay variability MSRV was detected within a single laboratory through nested and real-time PCR assays specific for pol and env genes. MSRV detection in blood and CSF of MS patients and controls in populations of different ethnicity gave significant differences (p<0.05 compared to neurological controls and <0.001 compared to healthy controls). The presence and viral load of MSRV are significantly associated with MS as compared to neurological and healthy controls in all ethnic groups.
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A 2007 study conducted a case-control in Multiple Sclerosis (n=302). MSRV particles vs. Neurological and healthy controls was evaluated on Presence and viral load of MSRV in blood and CSF (p=<0.05 compared to neurological controls and <0.001 compared to healthy controls). The presence and viral load of MSRV in blood and CSF were significantly associated with multiple sclerosis compared to neurological (p<0.05) and healthy controls (p<0.001) across all ethnic groups.
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