Key result
Concurrent acute illness was associated with a significantly higher 30-day all-cause mortality in patients with hemodynamically stable acute pulmonary embolism (OR 11.6, 95% CI 2.2-60.4, p=0.008).
Why the study?
While age, sex, chronic comorbidities, vital signs, and echocardiographic findings predict short-term mortality in acute pulmonary embolism, the impact of concurrent acute illness on prognosis is unclear.
Does concurrent acute illness increase 30-day all-cause mortality in patients with hemodynamically stable acute pulmonary embolism?
Cohort (n=130)
No
Does concurrent acute illness increase 30-day all-cause mortality in patients with hemodynamically stable acute pulmonary embolism?
Odds Ratio: 11.6 (95% CI 2.2–60.4)
Absolute Event Rate: 37.5% vs 4.9%
p-value: p=0.008
Concurrent acute illness is a significant prognostic factor associated with increased 30-day mortality in patients with hemodynamically stable acute pulmonary embolism.
May flag higher short-term mortality risk among stable PE patients; hypothesis-generating and requires prospective validation before practice change.
Objective: Acute pulmonary embolism (PE) is potentially fatal. Age, sex, chronic comorbidities, vital signs, and echocardiographic findings are well-known predictive indicators of the short-term mortality. However, the impact of concurrent acute illness on the prognosis is unclear.
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Kobayashi et al. (2023) conducted a cohort in Hemodynamically stable acute pulmonary embolism (n=130). Concurrent acute illness vs. No concurrent acute illness was evaluated on 30-day all-cause mortality (OR 11.6, 95% CI 2.2-60.4, p=0.008). Concurrent acute illness was associated with a significantly higher 30-day all-cause mortality in patients with hemodynamically stable acute pulmonary embolism (OR 11.6, 95% CI 2.2-60.4, p=0.008).
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