Key result
Screening of 64 Chinese women with polycystic ovary syndrome identified zero mutations in the coding regions of the follistatin gene.
Why the study?
Are mutations in the coding regions of the follistatin gene present in Chinese women with polycystic ovary syndrome?
Cross-Sectional (n=64)
Are mutations in the coding regions of the follistatin gene present in Chinese women with polycystic ovary syndrome?
Mutations in the coding regions of the follistatin gene do not appear to be the cause of PCOS in the local Chinese population.
Answers are grounded in this paper and cite their sources.
No follistatin coding mutations in this Chinese PCOS cohort; leaves open ethnic differences or non-coding mechanisms for further study.
Strong evidence for a link between the follistatin gene and polycystic ovary syndrome (PCOS) has recently been found in a well-designed large-scale study. Follistatin binds to activin and affects its functions, e.g. stimulation of FSH synthesis and secretion. Thus, it may play a role in the functional impairment of the FSH-granulosa cell axis in PCOS. In this study, we screened 64 Chinese patients with PCOS for mutations in the entire coding region (including the region encoding alternative carboxy-terminals) of the follistatin gene using polymerase chain reaction (PCR)-based single-stranded conformational polymorphism (SSCP) and DNA sequencing. However, we could not identify a single mutation of either the activating or inhibiting type, using these techniques. Therefore, it would appear that PCOS in the local Chinese population is not caused by mutations in the coding regions of the follistatin gene.
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Wu Xiang Liao (2000) conducted a cross-sectional in polycystic ovary syndrome (n=64). Follistatin gene mutations was evaluated on Mutations in the entire coding region of the follistatin gene. Screening of 64 Chinese women with polycystic ovary syndrome identified zero mutations in the coding regions of the follistatin gene.
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