Key result
Follistatin gene variants show weak linkage to PCOS, suggesting a small etiological contribution.
Why the study?
The strongest evidence for genetic linkage to PCOS was found with the region of the follistatin gene, but its relevance to PCOS was unclear.
Are allelic variants of the follistatin gene associated with polycystic ovary syndrome?
Population
85 members of 19 PCOS families for sequencing; 249 PCOS families for linkage analysis; cultured fibroblasts from PCOS and control women
Comparison
Follistatin gene variants and expression in PCOS patients versus controls
Design
Observational genetic sequencing and expression study
Authors
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Follistatin variants unlikely to drive PCOS etiology; leaves open search for other major susceptibility loci.
Observational
Are allelic variants of the follistatin gene associated with polycystic ovary syndrome?
The follistatin gene is unlikely to make a major contribution to the etiology of polycystic ovary syndrome.
Urbanek et al. (2000) conducted an observational in Polycystic ovary syndrome (PCOS). Follistatin gene variants was evaluated on Genetic linkage between PCOS and follistatin gene variants. Allelic variants of the follistatin gene showed weak evidence for linkage with polycystic ovary syndrome, suggesting their contribution to the etiology of PCOS is likely small.