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February 28, 2004MoleculesOpen Access

Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

Ibrahim M. Abdou Ayman Saleh Hussein F. Zohdi

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Abstract

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by (1)H and (13)C-NMR spectroscopy. Glucoside 3b shows an in vitro IC(50) value of 16.4 muM against proliferation of the human promyelotic leukemia (HL60) cell line.

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Abdou et al. (2004) studied this question.

synapsesocial.com/papers/6a9d7fbad8a02169be46ea3f https://doi.org/10.3390/90300109

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Synthesis of 1‐aryl‐5‐(trifluoromethyl)‐1H‐pyrazole‐4‐carboxylic acids and estersOriginal Research · 1987 · 18 citations
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