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September 1, 1989The Journal of Clinical Endocrinology & Metabolism

Detailed Assessment of Big Big Prolactin in Women with Hyperprolactinemia and Normal Ovarian Function

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Authors

IFIan S. FraserExpro (United Kingdom)ZLZHUANG GUANG LUNJZJIAN PING ZHOU

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Implication

Physiological study observes altered hormonal reactivity of big big prolactin in hyperprolactinemic women, indicating distinct regulation from monomeric prolactin.

Key Points

  • To examine the physiological dynamics, regulation, and potential carrier proteins of big big prolactin in women with hyperprolactinemia who maintain normal ovarian function.
  • Evaluated 6 women with elevated big big prolactin across the menstrual cycle, pregnancy (n = 5), and suckling (n = 1).
  • Conducted dynamic endocrine testing with thyrotropin-releasing hormone (TRH) stimulation and bromocriptine suppression (n = 3), alongside plasma binding assays.
  • TRH induced a 363 ± 116% rise in monomeric prolactin but only a 17.5 ± 7.4% rise in big big prolactin; bromocriptine suppressed prolactin by 81.8 ± 34.4% versus 21.0 ± 8.7% for big big prolactin at 6 hours (n = 3).
  • Big big prolactin rose during the preovulatory phase and pregnancy, but suckling triggered a 93% surge in monomeric prolactin without altering big big prolactin (n = 1).
  • Binding experiments showed no evidence of a specific circulating prolactin-binding protein responsible for big big prolactin.

Cite This Study

Fraser et al. (1989) studied this question.

synapsesocial.com/papers/6a9d8b6885bdd799da46dba9https://doi.org/10.1210/jcem-69-3-585
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Size Heterogeneity of Human Prolactin in Plasma and Pituitary Extracts1974 · 216 citations
  2. 2The Circulating Growth Hormone (GH)-Binding Protein Complex: A Major Constituent of Plasma GH in Man*1988 · 172 citations
  3. 3Identification and characterization of specific binding proteins for growth hormone in normal human sera.1986 · 320 citations
  4. 4Heterogeneity of Human Growth Hormone and Prolactin Secreted<i>in Vitro</i>: Immunoassay and Radioreceptor Assay Correlations1975 · 109 citations
  5. 5Large Molecular Size Prolactin with Reduced Receptor Activity in Human Serum: High Proportion in Basal State and Reduction after Thyrotropin-Releasing Hormone*1979 · 91 citations