Key result
Migraine patients had significantly lower plasma levels of human urotensin-II during episodes (0.483 pg/mL) and between episodes (0.493 pg/mL) compared to controls (0.737 pg/mL).
Why the study?
Do plasma levels of human urotensin-II differ between migraine patients and healthy controls?
Case-Control (n=54)
Do plasma levels of human urotensin-II differ between migraine patients and healthy controls?
Plasma levels of human urotensin-II are significantly lower in migraine patients compared to controls, suggesting a potential role in migraine pathogenesis.
Answers are grounded in this paper and cite their sources.
Should not yet influence migraine management; leaves open a possible pathogenic role pending validation.
Our aim was to determine the levels of human urotensin-II (hU-II) in the plasma of migraine patients and controls, to ascertain if there were a difference in the pathogenesis of migraine. A total of 27 patients who suffer from migraines and 27 controls were included in the study. Venous blood samples were drawn twice both from migraine patients and controls to measure hU-II plasma levels. The average levels of hU-II during migraine episode, between episodes, and controls were found to be 0.483, 0.493, and 0.737 pg/mL, respectively. The levels of hU-II in the controls were higher significantly. When comparisons were made according to sex, age groups, and types and durations of migraine, there was no significant difference in the levels of hU-II in the patients. The low levels of hU-II in the plasma of migraine patients compared with controls may be an indicator of its role in the pathogenesis.
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Bıçak et al. (2008) conducted a case-control in Migraine (n=54). Migraine vs. Controls was evaluated on Plasma levels of human urotensin-II (hU-II). Migraine patients had significantly lower plasma levels of human urotensin-II during episodes (0.483 pg/mL) and between episodes (0.493 pg/mL) compared to controls (0.737 pg/mL).
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