Why the study?
Does exogenous urotensin-II administration alter vascular tone differently in patients with essential hypertension compared to normotensive subjects?
Population
27 subjects, comprising patients with essential hypertension (n=13) and normotensive subjects (n=14).
Comparison
Exogenous urotensin-II administered via… vs Baseline measurements and normotensive control…
Design
Case-control
Authors
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Supports U-II contributing to vascular tone in hypertension; hypothesis-generating and requires prospective validation before clinical consideration.
Does exogenous urotensin-II administration alter vascular tone differently in patients with essential hypertension compared to normotensive subjects?
Exogenous urotensin-II causes vasoconstriction in hypertensive patients but vasodilation in normotensive subjects, suggesting its role in the increased vascular tone of essential hypertension.
Sondermeijer et al. (2005) studied this question.
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