Why the study?
Does central urotensin II alter arterial pressure and heart rate in conscious rats?
Population
Conscious Wistar rats
Comparison
Intracerebroventricular injections of urotensin… vs ICV injection of artificial cerebrospinal fluid
Design
Preclinical
Follow-up
15 minutes
Authors
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Does not inform clinical hypertension management; extends mechanistic understanding of urotensin II in conscious rats.
Does central urotensin II alter arterial pressure and heart rate in conscious rats?
Central urotensin II produces pressor and tachycardic responses through sympathetic activation, while peripheral urotensin II exerts a vasodilation-mediated depressor response in conscious rats.
Lin et al. (2003) studied this question.
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