April 1, 2001British Journal of PharmacologyOpen Access

Depressor and regionally‐selective vasodilator effects of human and rat urotensin II in conscious rats

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Why the study?

Does human or rat urotensin II affect regional haemodynamics in conscious rats?

Population

Conscious, unrestrained, male, Sprague-Dawley rats (n=8 in each group)

Design

Preclinical

Authors

SGSheila M. GardinerUniversity of Nottingham JMJ E MarchUniversity of Nottingham PKP.A. KempAnalytical Engineering (United States)

Discussion

Member takes

Implication

Induces predominant vasodilatation in conscious rats; challenges primate data and leaves open human translation.

Structured PICO

Does human or rat urotensin II affect regional haemodynamics in conscious rats?

Population

Conscious, unrestrained, male, Sprague-Dawley rats (n=8 in each group)

Intervention

Rat or human urotensin II (U-II) at doses of 3, 30, 300, and 3000 pmol kg(-1), i.v.

Outcome

Regional haemodynamic effectssurrogate

In conscious rats, the predominant cardiovascular action of rat and human urotensin II is vasodilatation, which contrasts with findings in non-human primates.

Cite This Study

Gardiner et al. (2001) studied this question.

synapsesocial.com/papers/6a990ee2e8ca4d2af6363262 https://doi.org/10.1038/sj.bjp.0704051

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