Population
Rodents, dogs, and primates (in vitro arteries and in vivo anesthetized primates)
Comparison
Human urotensin-II (U-II) vs Endothelin-1 (ET-1) for in vitro comparison
Design
Preclinical
Authors
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U-II's primate lethality cautions against agonist therapies; leaves open its role in human cardiovascular disease.
Human urotensin-II is identified as one of the most potent mammalian vasoconstrictors to date, with significant species-dependent effects and profound hemodynamic consequences in primates.
Douglas et al. (2000) studied this question.
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