September 1, 2000British Journal of PharmacologyOpen Access

Human urotensin‐II is a potent spasmogen of primate airway smooth muscle

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Population

Primate airway and pulmonary vascular tissues

Design

Preclinical

Authors

DHDouglas W.P. HayUniversité Claude Bernard Lyon 1 MLMark A. LuttmannEuropean Federation of Allergy and Airways Diseases Patients Associations SDStephen A. DouglasUniversity of Minnesota

Discussion

Member takes

Implication

Suggests urotensin-II may contribute to pulmonary tone; leaves open its role in human lung disease.

Structured PICO

Population

Primate airway and pulmonary vascular tissues

Intervention

Human urotensin-II (hU-II)

Outcome

Contractile profile (potency and efficacy/maximum contraction)surrogate

Human urotensin-II exhibits potent contractile activity in primate airway and pulmonary vascular tissues, suggesting a potential pathophysiological role in lung diseases.

Cite This Study

Hay et al. (2000) studied this question.

synapsesocial.com/papers/6a990ee2e8ca4d2af6363264 https://doi.org/10.1038/sj.bjp.0703533

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Human urotensin‐II is a potent spasmogen of primate airway smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Human urotensin‐II is a potent spasmogen of primate airway smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider