Effects of Urotensin II in Human Arteries and Veins of Varying Caliber
Why the study?
Does human Urotensin II cause vasoconstriction in human arteries and veins?
Population
Human blood vessels and rat thoracic aorta
Comparison
Human Urotensin II (hUII) vs Norepinephrine and endothelin-1
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Species differences caution against rodent extrapolation; leaves open urotensin II's role in human cardiovascular regulation.
Structured PICO
Does human Urotensin II cause vasoconstriction in human arteries and veins?
P
Population
Human blood vessels (small subcutaneous resistance arteries, internal mammary arteries, saphenous veins, and small subcutaneous veins) and rat thoracic aorta
I
Intervention
Human Urotensin II (hUII)
C
Comparator
Norepinephrine and endothelin-1 (as positive controls)
O
Outcome
Vasoconstriction (tension)surrogate
Human Urotensin II lacks vasoconstrictor action in human blood vessels, questioning its importance in human cardiovascular regulation due to marked species differences.
Cite This Study
Hillier et al. (2001) studied this question.