Key result
Essential hypertension and renal tubular abnormality are linked to elevated urinary urotensin-II levels.
Population
Normal individuals, patients with essential hypertension, patients with renal tubular abnormality, and…
Design
Cross-sectional
Authors
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Supports potential urotensin-II involvement in hypertension with renal tubular changes; hypothesis-generating and requires prospective validation before clinical consideration.
Observational
Human Urotensin-II is abundantly expressed in cardiovascular and renal tissues and elevated in the urine of patients with essential hypertension, suggesting a role as an autocrine/paracrine vasoactive factor.
Matsushita et al. (2001) conducted an observational in Essential hypertension and renal tubular abnormality. Essential hypertension and renal tubular abnormality vs. Normal individuals was evaluated on Urinary hUII concentrations. Urinary urotensin-II concentrations were significantly greater in patients with essential hypertension and renal tubular abnormality compared to normal individuals (7.4 +/- 0.9 microg/g creatinine).
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