Key result
In medically treated patients with severe isolated aortic stenosis and preserved LVEF, the combination of age ≥78 years, hypertension, left atrial diameter ≥40 mm, and PASP ≥42 mmHg predicted all-cause mortality with a joint AUC of 0.80.
Cohort (n=241)
No
Effect estimate: AUC 0.80 (95% CI 0.73-0.86)
Authors
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May stratify mortality risk in medically managed severe AS; leaves open utility for guiding valve replacement timing.
Barasch et al. (2013) conducted a cohort in Severe isolated aortic stenosis with preserved left ventricular ejection fraction (n=241). Clinical and echocardiographic risk factors (age ≥78 years, hypertension, LAD ≥40 mm, PASP ≥42 mmHg) vs. Absence of these risk factors was evaluated on All-cause mortality (AUC 0.80, 95% CI 0.73-0.86). In medically treated patients with severe isolated aortic stenosis and preserved LVEF, the combination of age ≥78 years, hypertension, left atrial diameter ≥40 mm, and PASP ≥42 mmHg predicted all-cause mortality with a joint AUC of 0.80.
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