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October 15, 2025Reproductive HealthOpen Access

Pregnancy and obstetric-neonatal outcomes of patients with thin endometrium using three different endometrial preparation protocols in frozen embryo transfer cycles: a historical cohort of 2671 patients

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Authors

HHHaoming HuangKunming University of Science and Technology JZJiayin ZhouHong Kong Polytechnic University YLYan LiBrigham and Women's Hospital

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Implication

Cohort study finds equivalent live birth rates across three endometrial preparation protocols in women with thin endometrium, suggesting protocol choice may not alter major outcomes.

Key Points

To compare pregnancy and obstetric-neonatal outcomes across three endometrial preparation protocols in women with thin endometrium undergoing frozen embryo transfer.
Conducted a historical cohort study of 2,671 women with thin endometrium (<8 mm on the first day of progesterone administration) undergoing their first frozen embryo transfer cycle between January 2018 and August 2022, with follow-up through August 2023.
Categorized patients into three endometrial preparation protocols: natural cycle (NC; n=257), artificial cycle (AC; n=1,908), and AC with gonadotropin-releasing hormone agonist pretreatment (GnRH-a + AC; n=506), with a subgroup analysis conducted for thickness <7 mm.
For patients with endometrial thickness <8 mm, clinical pregnancy rates were 36.2% (691/1,908) in AC, 35.2% (178/506) in GnRH-a + AC, and 33.9% (87/257) in NC, with live birth rates of 26.8% (512/1,908), 25.3% (128/506), and 27.6% (71/257), showing no significant pairwise differences.
Biochemical pregnancy loss was significantly lower in the NC group than in the AC group (3.9% vs. 8.6%, P < 0.05; crude OR 0.428, 95% CI [0.223, 0.821]; adjusted OR 0.444, 95% CI [0.230, 0.856]).
In the subgroup with endometrial thickness <7 mm, no statistically significant differences in pregnancy or obstetric-neonatal outcomes were detected across the three preparation protocols.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/6a9da4b13fe8c5aa642a08ba https://doi.org/10.1186/s12978-025-02166-z

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Implication

Cohort study finds equivalent live birth rates across three endometrial preparation protocols in women with thin endometrium, suggesting protocol choice may not alter major outcomes.

Pregnancy and obstetric-neonatal outcomes of patients with thin endometrium using three different endometrial preparation protocols in frozen embryo transfer cycles: a historical cohort of 2671 patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Pregnancy and obstetric-neonatal outcomes of patients with thin endometrium using three different endometrial preparation protocols in frozen embryo transfer cycles: a historical cohort of 2671 patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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