Key result
Tei index and plasma NT-proBNP demonstrated a fair correlation (r=0.75, p<0.0001) and their addition to a clinical model significantly improved the prediction of functional status.
Why the study?
Do Tei index and NT-proBNP correlate and predict functional status improvement in patients with incident left ventricular dysfunction?
Observational (n=150)
Do Tei index and NT-proBNP correlate and predict functional status improvement in patients with incident left ventricular dysfunction?
Effect estimate: r=0.75
p-value: p=<0.0001
Tei index and NT-proBNP correlate well and can help identify patients with incident left ventricular dysfunction who are unlikely to experience functional improvement.
May support risk stratification in incident LV dysfunction; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: Natriuretic peptides and Tei index are useful indices for risk stratification in advanced left ventricular dysfunction (LVD). Their role in early stages is less clear. AIMS: In relation to first diagnosis of LVD to assess the relation of plasma B-type-natriuretic peptide (NT-proBNP) with Tei index, assess serial changes in indices, and to assess the value of indices to predict functional status. METHODS: Doppler echocardiography and neurohormonal analysis were performed (n=150). NYHA class was registered. RESULTS: Tei index correlated with p-NT-proBNP (r=0.75, p<0.0001), and changes in indices correlated (r=0.36, p=0.001) in LVD (n=80). No functional improvement (n=47) was related to a median increase in Tei index (-0.2, -0.16; 0.09); an improvement (n=31) to a reduction (0.06; -0.19; 0.35), p=0.02. In the group with functional improvement, more patients had >/=30% reduction in p-NT-proBNP (75% vs. 45%, p<0.01). Addition of NT-proBNP or Tei index to a clinical model, of no functional improvement, improved log-likelihood chi(2) from 9.32 to 20.18 (p=0.001) and 20.67 (p=0.001). CONCLUSION: Tei index and p-NT-proBNP demonstrated a fair correlation. Unimproved NYHA class was related to progressive LVD and might be identified by monitoring Tei index or p-NT-proBNP. Advanced LVD and high pre-treatment p-NT-proBNP levels indicated a potential of improvement in functional status.
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Møller et al. (2006) conducted an observational in Incident Heart Failure / Left ventricular dysfunction (n=150). Tei index and NT-proBNP was evaluated on Correlation between Tei index and p-NT-proBNP (r=0.75, p=<0.0001). Tei index and plasma NT-proBNP demonstrated a fair correlation (r=0.75, p<0.0001) and their addition to a clinical model significantly improved the prediction of functional status.
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