Key result
Chronic hypoxia and acute ischaemic preconditioning independently increased myocardial tolerance to ischaemia in a rat model, improving recovery of developed pressure during reperfusion.
Why the study?
Does acute ischaemic preconditioning and chronic hypoxia improve myocardial tolerance to ischaemia in isolated rat hearts?
Population
Rat model of three week hypoxia and normoxic controls
Comparison
Chronic hypoxia and/or acute ischaemic… vs Normoxic control without preconditioning
Design
Preclinical
Authors
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Should not yet change clinical ischaemia management; leaves open independent cardioprotective effects of hypoxia and preconditioning for translational validation.
Does acute ischaemic preconditioning and chronic hypoxia improve myocardial tolerance to ischaemia in isolated rat hearts?
Chronic hypoxia and acute ischaemic preconditioning independently increase myocardial tolerance to severe ischaemia in a rat model.
Tajima et al. (1994) studied Myocardial ischaemia. Chronic hypoxia and acute ischaemic preconditioning vs. Normoxic control was evaluated on Systolic and diastolic functions during a 15 or 20 min period of ischaemia and reperfusion. Chronic hypoxia and acute ischaemic preconditioning independently increased myocardial tolerance to ischaemia in a rat model, improving recovery of developed pressure during reperfusion.
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