Why the study?
Does hypoxic preconditioning improve functional recovery and preserve antioxidant reserve in isolated working rat hearts subjected to ischaemia-reperfusion?
Does hypoxic preconditioning improve functional recovery and preserve antioxidant reserve in isolated working rat hearts subjected to ischaemia-reperfusion?
Hypoxic preconditioning enhances functional recovery and reduces cell necrosis following global ischaemia in the working rat heart, potentially mediated by enhanced ascorbate and thiol components of the antioxidant reserve.
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Does not support clinical use; extends preclinical evidence for hypoxic preconditioning in rat ischemia-reperfusion.
Engelman et al. (1995) studied this question.
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