Why the study?
Does hypoxic preconditioning improve functional recovery and preserve antioxidant reserve in isolated working rat hearts subjected to ischaemia-reperfusion?
Population
Isolated working rat hearts subjected to 30 min ischaemia and 30 min reperfusion
Comparison
Hypoxic preconditioning with 10 min hypoxia vs Non-preconditioned control hearts
Design
Preclinical
Follow-up
30 min reperfusion
Authors
Loading...
Does not support clinical use; extends preclinical evidence for hypoxic preconditioning in rat ischemia-reperfusion.
Does hypoxic preconditioning improve functional recovery and preserve antioxidant reserve in isolated working rat hearts subjected to ischaemia-reperfusion?
Hypoxic preconditioning enhances functional recovery and reduces cell necrosis following global ischaemia in the working rat heart, potentially mediated by enhanced ascorbate and thiol components of the antioxidant reserve.
Engelman et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: