December 7, 2015Oxidative Medicine and Cellular LongevityOpen Access

The Responses of Tissues from the Brain, Heart, Kidney, and Liver to Resuscitation following Prolonged Cardiac Arrest by Examining Mitochondrial Respiration in Rats

Q: What is the clinical evidence from this study?

Study design: Other. Population: Prolonged cardiac arrest. Intervention: Cardiopulmonary bypass resuscitation vs. Cardiac arrest without resuscitation. Primary outcome: Mitochondrial state-3 respiration activity.

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Key result

Cardiopulmonary bypass resuscitation after cardiac arrest yielded varied brain mitochondrial respiration, unchanged heart respiration, and significantly increased kidney and liver respiration.

Population

Male Sprague-Dawley rats

Design

Preclinical

Follow-up

60 minutes (post-resuscitation)

Authors

JKJun Hwan KimUlsan College JVJosé Paul Perales VillarroelUniversity of Pennsylvania WZWei ZhangNorthwestern University

Discussion

Member takes

Implication

Does not support clinical protocol changes; leaves open mitochondrial respiration as an organ-specific marker in arrest models.

Structured PICO

Population

Male Sprague-Dawley rats subjected to asphyxia-induced cardiac arrest for 30 or 45 minutes, with or without 60 minutes of cardiopulmonary bypass resuscitation.

Intervention

Asphyxia-induced cardiac arrest for 30 min or 45 min, or 30 min cardiac arrest followed by 60 min cardiopulmonary bypass resuscitation

Outcome

Mitochondrial state-3 respiration activity in brain, heart, kidney, and liver tissuessurrogate

Inhibition of state-3 mitochondrial respiration serves as a marker to evaluate organ-specific resuscitation efficacy following prolonged cardiac arrest, highlighting the need for better strategies for brain and heart recovery.

Cite This Study

Kim et al. (2015) studied Prolonged cardiac arrest. Cardiopulmonary bypass resuscitation vs. Cardiac arrest without resuscitation was evaluated on Mitochondrial state-3 respiration activity. Cardiopulmonary bypass resuscitation after cardiac arrest yielded varied brain mitochondrial respiration, unchanged heart respiration, and significantly increased kidney and liver respiration.

synapsesocial.com/papers/6a9da8aba99ff5a58a680d1e https://doi.org/10.1155/2016/7463407

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December 7, 2015Oxidative Medicine and Cellular LongevityOpen Access

The Responses of Tissues from the Brain, Heart, Kidney, and Liver to Resuscitation following Prolonged Cardiac Arrest by Examining Mitochondrial Respiration in Rats

View Full Paper

Ask AI

Bookmark

Key result

Cardiopulmonary bypass resuscitation after cardiac arrest yielded varied brain mitochondrial respiration, unchanged heart respiration, and significantly increased kidney and liver respiration.

Population

Male Sprague-Dawley rats

Design

Preclinical

Follow-up

60 minutes (post-resuscitation)

Authors

JKJun Hwan KimUlsan College JVJosé Paul Perales VillarroelUniversity of Pennsylvania WZWei ZhangNorthwestern University

Discussion

Member takes

Implication

Does not support clinical protocol changes; leaves open mitochondrial respiration as an organ-specific marker in arrest models.

Structured PICO

Population

Male Sprague-Dawley rats subjected to asphyxia-induced cardiac arrest for 30 or 45 minutes, with or without 60 minutes of cardiopulmonary bypass resuscitation.

Intervention

Asphyxia-induced cardiac arrest for 30 min or 45 min, or 30 min cardiac arrest followed by 60 min cardiopulmonary bypass resuscitation

Outcome

Mitochondrial state-3 respiration activity in brain, heart, kidney, and liver tissuessurrogate

Cite This Study

synapsesocial.com/papers/6a9da8aba99ff5a58a680d1e https://doi.org/10.1155/2016/7463407

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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