Key result
The eNOS gene (G894T) polymorphism was not associated with hypertension or nitric oxide levels in diabetic Bataknese patients (NO level 88.87 vs 95.42 µmol/L; p=0.54).
Why the study?
The study was conducted to assess endothelial nitric oxide synthase gene G894T polymorphism and nitric oxide level in hypertensive diabetic Bataknese patients.
Is the eNOS gene (G894T) polymorphism associated with hypertension and NO levels in diabetic Bataknese patients?
Case-Control
Is the eNOS gene (G894T) polymorphism associated with hypertension and NO levels in diabetic Bataknese patients?
Absolute Event Rate: 88.87% vs 95.42%
p-value: p=0.54
The eNOS gene (G894T) polymorphism is not significantly associated with nitric oxide levels or hypertension in diabetic Bataknese patients.
No clinical role for eNOS G894T testing in this group; leaves open ethnic-specific genetic links needing larger studies.
Aim To assess endothelial nitric oxide synthase (eNOS) gene (G894T) polymorphism and nitric oxide (NO) level in hypertensive diabetic Bataknese patients. Methods A hospital-based, case control study (hypertensive and normotensive diabetic patient) was conducted. Genotyping of eNOS gene (G894T) was done using polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP). Nitric oxide was quantified by sandwich enzyme-linked immunosorbent assay (Sandwich ELISA). Results GT polymorphism and T allele were higher in the hypertensive diabetic patients, 37.5% (p=0.6) and 54% (p=0.39), respectively. Nitric oxide level tended to be lower in the hypertensive diabetic patients (88.87µmol/L) comparing to the normotensive (95.42 µmol/L (p=0.54), as well as GT and TT polymorphism type (p=0.75). Conclusion eNOS gene (G894T) polymorphism is not associated with NO level and hypertension in the diabetic Bataknese patients.
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Siregar et al. (2020) conducted a case-control in Hypertension in diabetic patients. eNOS gene (G894T) polymorphism vs. Normotensive diabetic patients was evaluated on Nitric oxide level (µmol/L) (p=0.54). The eNOS gene (G894T) polymorphism was not associated with hypertension or nitric oxide levels in diabetic Bataknese patients (NO level 88.87 vs 95.42 µmol/L; p=0.54).
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