Key result
Pulse pressure index measured during endovascular aneurysm repair was positively correlated with aneurysm enlargement at 3 months.
Why the study?
Abdominal aortic aneurysm enlargement and rupture occur despite EVAR and have been linked to increased aneurysm sac pressure, motivating research into correlations between intraprocedural pressure and subsequent enlargement.
Does intra-aneurysm sac pressure measurement during EVAR predict subsequent aneurysm enlargement in patients with infrarenal AAAs?
Cohort (n=30)
Does intra-aneurysm sac pressure measurement during EVAR predict subsequent aneurysm enlargement in patients with infrarenal AAAs?
Intra-aneurysm sac pulse pressure index measured during EVAR may serve as an early prognostic factor for subsequent aneurysm enlargement, helping identify high-risk patients.
Purpose: Numerous cases of abdominal aortic aneurysm (AAA) enlargement, and even rupture, despite endovascular aneurysm repair (EVAR), have been documented. This has been linked to increased aneurysm sac pressure (ASP). We decided to conduct further research with the aim to identify correlations between ASP during EVAR and subsequent aneurysm enlargement. Patients and Methods: This experimental prospective study included 30 patients undergoing EVAR of infrarenal AAAs. Invasive ASP measurements were done using a thin pressure wire. Aortic pressure (AP) was measured using a catheter placed over the wire. Systolic pressure index (SPI), diastolic pressure index (DPI), mean pressure index (MPI), and pulse pressure index (PPI) were calculated both for ASP and AP. The results of follow-up computed tomography angiography (CTA) at 3 months were compared with baseline CTA findings. Results: During EVAR, a significant reduction was observed for SPI (from 98% to 61%), DPI (from 100% to 87%), MPI (from 99% to 74%), and PPI (from 97% to 34%). There were no significant correlations of pressure indices with an aneurysm diameter, cross-sectional area, velocity, thrombus shape and size, number of patent lumbar arteries, length and diameter of aneurysm neck, diameter of the inferior mesenteric artery, as well as diameter and angle of common iliac arteries. On the other hand, aneurysm neck angulation was significantly inversely correlated with reduced PPI. After combining CTA findings with pressure measurements, we identified a positive correlation between PPI and aneurysm enlargement (ratio of the cross-sectional area at the widest spot at baseline and at 3 months after EVAR). Conclusion: The study showed that ASP can be successfully measured during EVAR and can facilitate the assessment of treatment efficacy. In particular, PPI can serve as a prognostic factor of aneurysm enlargement and can help identify high-risk patients who remain prior monitoring.
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Antkiewicz et al. (2022) conducted a cohort in Infrarenal abdominal aortic aneurysms (n=30). Intra-aneurysm sac pressure measurement (Pulse Pressure Index) was evaluated on Correlation between pulse pressure index and aneurysm enlargement at 3 months. Pulse pressure index measured during endovascular aneurysm repair was positively correlated with aneurysm enlargement at 3 months.
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