Key result
Patients with pT3 renal cell carcinoma harboring both extrarenal tumor extension and venous tumor thrombus had a significantly higher risk of death from RCC (HR 2.660, P<0.001).
Cohort (n=419)
No
Hazard Ratio: 2.66
p-value: p=<.001
Subclassifying pT3 renal cell carcinoma patients based on the presence of both extrarenal tumor extension and venous tumor thrombus improves prognostic accuracy for cancer-specific survival compared to the 2002 AJCC classification.
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May improve pT3 RCC risk stratification; leaves open prospective validation before staging or management changes.
Margulis et al. (2007) conducted a cohort in pathologic T3 (pT3) renal cell carcinoma (n=419). Concomitant extrarenal tumor extension (ERE) and venous tumor thrombus (VTT) vs. ERE only or VTT only was evaluated on Death from RCC (cancer-specific mortality) (HR 2.660, p=<.001). Patients with pT3 renal cell carcinoma harboring both extrarenal tumor extension and venous tumor thrombus had a significantly higher risk of death from RCC (HR 2.660, P<0.001).